ABSORPTION • When we take oral drug then it goes Into the stomach and after disintegration and dissolution it absorb into blood. • Absorption is the first step of pharmacokinetics . • In disintegration step drug break into small particle in the presence of gastric HCl. • After disintegration drug dissolve into gastric HCl and absorb into systemic circulation. Factor affecting drug absorption : Drug absorption is depends upon following factor - (1) Physiochemical properties of drug (2) Physiological factor (3) Nature of dosage form (4) Route of drug administration (5) Bioavailability (1) PHYSIOCHEMICAL PROPERTIES OF DRUG : (A) Particle size - • The absorption of of drug is inversely proportional to the particle size. • As well as the particle size of drugs increase the rate of absorption is decreased. • And when the particle size is decrease then the rate of absorption is increase. (B) Nature of dosage form of drug - • The nature of any powder is of two types amorphous or crystal...
Professional Mock Test Platform ExamPro 00:00 Pause Instructions Negative Marking: Off ? Question 1 of 2 00:00 1. Identify the animal in the image Figure: Animal in its natural habitat Previous Clear Save & Next ...
{ id: 1, text: "Which of the following respective Phase-I and Phase-II reactions are the most common drug biotransformation reactions?", options: ["(A) Oxidation and Glucuronidation", "(B) Reduction and Acetylation", "(C) Hydrolysis and Glucuronidation", "(D) Oxidation and Glutathione conjugation"], correct: 0, userAnswer: null, timeSpent: 0, explanation: "No Explanation" }, { id: 2, text: "Which one of the following drugs has positive inotropic and negative chronotropic action?", options: ["(A) Dopamine", "(B) Epinephrine", "(C) Digoxin", "(D) Isoprenaline"], correct: 2, userAnswer: null, timeSpent: 0, explanation: "No Explanation" }, { id: 3, text: "Which one of the following therapeutic classes has been proved clinically as a first-line therapy for heart failure and has shown decreased hospitalization, improved symptoms, and d...
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