Absorption of drug | Factor affecting absorption | b pharmacy
ABSORPTION • When we take oral drug then it goes Into the stomach and after disintegration and dissolution it absorb into blood. • Absorption is the first step of pharmacokinetics . • In disintegration step drug break into small particle in the presence of gastric HCl. • After disintegration drug dissolve into gastric HCl and absorb into systemic circulation. Factor affecting drug absorption : Drug absorption is depends upon following factor - (1) Physiochemical properties of drug (2) Physiological factor (3) Nature of dosage form (4) Route of drug administration (5) Bioavailability (1) PHYSIOCHEMICAL PROPERTIES OF DRUG : (A) Particle size - • The absorption of of drug is inversely proportional to the particle size. • As well as the particle size of drugs increase the rate of absorption is decreased. • And when the particle size is decrease then the rate of absorption is increase. (B) Nature of dosage form of drug - • The nature of any powder is of two types amorphous or crystal...
Comments
Post a Comment